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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

Benefits of medical supervision include baseline health assessment before starting protocols, appropriate bloodwork monitoring, professional guidance on dosing and duration, recognition of potential adverse effects, and integration with other health treatments

This leads us to discuss dosage

Notably, in cancer, MSC-Exos may protect non-malignant tissues from chemotherapy-induced ferroptosis